Ortho-Cyclen contains a combination of female hormones, (ethinyl estradiol and norgestimate), that prevent ovulation (the release of an egg from an ovary). Started with Ortho Tri-Cylcen, switched to OrthoTri-Cyclen Lo, and this year switched to Tri-Sprintec (generic of Ortho Lo). I've really only noticed this issue since I started Tri-Sprintec. I'm wondering if it is to blame. I'm seeing my doctor for my yearly PAP on December 23rd and I will post my findings then. When I started the ortho-tri-cyclen, 5 years ago, i noticed I was getting anxiety and small panic attacks. Now, I am still on the ortho and have severe anxiety. I've been on paxil and therapy for a few months now, which has helped. I went down to ortho-lo to try a lower dose and my anxiety shot through the. Summary. Depression is found among people who take Ortho tri-cyclen, especially for people who are female, 20-29 old , have been taking the drug for 6 - 12 months, also take medication Accutane, and have Acne cystic. Summary. Drug interactions are reported among people who take Ortho tri-cyclen and Paxil together. This study is created by eHealthMe based on reports of 139 people who take Ortho tri-cyclen and Paxil from FDA, and is updated regularly. Find patient medical information for Ortho Tri-Cyclen LO (28) Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Generic Ortho Tri-Cyclen has been used for 25 years for the prevention of pregnancy in women! It is one of the most prescribed medications and you can order it here for a fraction of the price. It is one of the most prescribed medications and you can order it here for a fraction of the price. Generic Ortho Tri-Cyclen has been used for 25 years for the prevention of pregnancy in women! It is one of the most prescribed medications and you can order it here for a fraction of the price. It is one of the most prescribed medications and you can order it here for a fraction of the price. Our Ortho-Tri-Cyclen (ethinyl estradiol, norgestimate) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. I went from ortho tri cyclen lo, to ortho cyclen, to ortho tri cyclen. All of which have made me have anxiety. I was on the depo shot for years and beside minor bone loss i had no issues.